Research – Erudit http://erudit.media/ Fri, 28 May 2021 12:20:56 +0000 en-US hourly 1 https://wordpress.org/?v=5.7.2 https://erudit.media/wp-content/uploads/2021/05/default1-150x150.png Research – Erudit http://erudit.media/ 32 32 Army grant supports research into potential CRISPR therapy for familial ALS https://erudit.media/army-grant-supports-research-into-potential-crispr-therapy-for-familial-als/ https://erudit.media/army-grant-supports-research-into-potential-crispr-therapy-for-familial-als/#respond Fri, 28 May 2021 12:00:44 +0000 https://erudit.media/army-grant-supports-research-into-potential-crispr-therapy-for-familial-als/ Researchers at the University of Texas at Dallas (UT Dallas) received a U.S. Army Medical Research Acquisition Activity Award to advance their preclinical research on an innovative approach to gene editing based on CRISPR to treat one of the most common causes of familial amyotrophic laterality. sclerosis (ALS). The nearly $ 650,000 two-year award went […]]]>


Researchers at the University of Texas at Dallas (UT Dallas) received a U.S. Army Medical Research Acquisition Activity Award to advance their preclinical research on an innovative approach to gene editing based on CRISPR to treat one of the most common causes of familial amyotrophic laterality. sclerosis (ALS).

The nearly $ 650,000 two-year award went to the project’s principal investigator, Zhenghong Gao, PhD, a mechanical engineering researcher at UT Dallas’ Erik Jonsson School of Engineering and Computer Science, whose work focuses on nanotechnologies.

Some studies suggest that people who have served in the military are at greater risk of developing ALS than those who have no history of military service. However, there is no effective treatment to slow the progression of the disease.

Similar to the editing system used by bacteria as a defense mechanism, CRISPR allows researchers to modify parts of the genome by adding, removing or modifying specific sections of DNA.

With CRISPR-based treatments gaining increasing interest as potential therapies for familial ALS, which accounts for up to 10% of all cases, Gao’s approach has the potential to overcome one of the main barriers to treating ALS. neurological conditions – affecting the central nervous system (CNS, brain and spinal cord).

Typically, large molecules and microbes in the blood cannot reach the CNS due to the presence of a highly selective protective membrane called the blood brain barrier.

Since most gene therapies and gene editing approaches use modified and harmless adeno-associated viruses (AAVs) to transport and deliver a particular gene or the CRISPR machinery to cells, these treatments have a limited ability to achieve their target cells in the CNS.

“Our expertise in nanomaterials has provided a new method to remotely target and modulate this barrier,” said Zhenpeng Qin, PhD, co-investigator of the project and expert in the use of nanotechnologies to improve the treatment of brain diseases, in an academic press release.

The new approach uses light-sensitive gold nanoparticles that attach to the blood-brain barrier, after which the researchers apply short laser pulses. This causes the nanoparticles to generate soft mechanical energy that temporarily opens the barrier, allowing AAVs to pass through.

Once the virus enters target cells, the editing components of the CRISPR gene are released to correct the familial mutation causing ALS.

“Ideally, without the mutated gene, cells cannot [ALS-associated] more toxic proteins, and the disease cannot develop, ”Gao said.

“We hope that by improving the delivery of CRISPR therapy using our new barrier opening technology, we can significantly slow or even stop the progression of the disease,” Gao added.

“Our goal is to test in a small animal model the idea of ​​using CRISPR to suppress mutations as the sole treatment for inherited ALS,” Gao said, adding that the team will focus “on the first. removal of one of the “characterized mutations” responsible for familial ALS.

“If successful, we may be able to apply this new approach to remove or edit other mutations,” said the project leader. He also noted that in the long term, this type of approach can also be used to treat other neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease and Huntington’s disease.

Leonidas Bleris, PhD, co-principal investigator of the project at UT Dallas and a pioneer in gene editing, said that “CRISPR is an incredibly powerful tool” and that the team is “optimistic that in the near future, we will be able to perform surgical changes in the brain with single cell precision.

“The possibilities are endless,” added Bleris, who is also associate professor of bioengineering at UT Dallas and associate, Cecil H. and Ida Green, professor of systems biology science.

Still, Gao warned that the project is only just beginning and it could be years before this type of CRISPR-based gene editing approach becomes available to patients.

The multidisciplinary team also includes two ALS experts from Northwestern University Feinberg School of Medicine in Chicago, Illinois: Han-Xiang Deng, MD, PhD, and Evangelos Kiskini, PhD.

Marta Figueiredo holds a master’s degree in evolutionary and developmental biology and a doctorate in biomedical sciences from the University of Lisbon, Portugal. His research focuses on the role of several signaling pathways in the embryonic development of the thymus and parathyroid glands.

Total Posts: 45

Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in the biology of blood vessels, blood stem cells and cancer. Previously, she studied cellular and molecular biology at the Universidade Nova de Lisboa and worked as a research fellow at the Faculdade de Ciências e Tecnologias and at the Instituto Gulbenkian de Ciência. Inês currently works as a science editor, striving to deliver the latest scientific advances to patient communities in a clear and precise manner.



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SFU and UBC researchers collaborate to understand the role of caveolin-1 in cancer https://erudit.media/sfu-and-ubc-researchers-collaborate-to-understand-the-role-of-caveolin-1-in-cancer/ https://erudit.media/sfu-and-ubc-researchers-collaborate-to-understand-the-role-of-caveolin-1-in-cancer/#respond Thu, 27 May 2021 17:51:51 +0000 https://erudit.media/sfu-and-ubc-researchers-collaborate-to-understand-the-role-of-caveolin-1-in-cancer/ PICTURE: Ghassan Hamarneh, professor of computer science at SFU, uses his expertise in medical imaging analysis to help UBC researchers understand the role of caveolin-1 (CAV1) in certain types of cancer. view After Credit: SFU Ghassan Hamarneh, professor of computer science at SFU, uses his expertise in medical imaging analysis to help UBC researchers understand […]]]>


PICTURE: Ghassan Hamarneh, professor of computer science at SFU, uses his expertise in medical imaging analysis to help UBC researchers understand the role of caveolin-1 (CAV1) in certain types of cancer. view After

Credit: SFU

Ghassan Hamarneh, professor of computer science at SFU, uses his expertise in medical imaging analysis to help UBC researchers understand the role of caveolin-1 (CAV1) in certain types of cancer.

CAV1 is a protein associated with poor performance in aggressive breast and prostate cancers. It is also associated with tumor metastasis and tumor suppression, but it is not known how CAV1 differentiates these two roles.

UBC biologist Ivan Robert Nabi and his team are studying the contribution of CAV1. They do this by using machine learning-based super-resolution microscopy analyzes to study and visualize caveolae and scaffolding – tiny structures that are found in a cell and in which CAV1 is found.

Using a graph-based approach, Hamarneh and the other researchers are able to capture and process three-dimensional coordinates of data, called point clouds, with nanometric resolution to view cellular processes.

Given the complexity and volume of data, manual filtering of all of this data is inefficient. For this reason, researchers use computer vision and artificial intelligence (AI) methods to automatically analyze the data. This is done through classic machine learning approaches where researchers train the machines to examine specific characteristics and feed the data into an algorithm. They also use deep learning approaches in which researchers do not impose their own bias in terms of the features they seek to examine and allow the machine to find out which features stand out.

“With deep learning, the machine discovers features for you, but sometimes those features are not easily interpreted,” says Hamarneh.

“We’re looking at interpretable AI methods, where we take a look at what the AI ​​has discovered and expose it to biologists to get a glimpse of it.”

Since starting their collaboration a few years ago, Hamarneh and Nabi have combined their expertise to develop software tools to make this process possible. Together with SFU postdoctoral researcher Ismail Khater, they developed super-resolution network analysis, which helps researchers analyze biological clusters and can be applied to different biological questions.

Their research efforts have not gone unnoticed. Recently, the research groups received $ 910,000 from the Canadian Institutes of Health Research (CIHR) for the next five years.

“We are very happy with this funding because it allows us to continue this work and, most importantly, to provide salaries to graduate students and post-docs to help us in our research,” says Hamarneh.

“Receiving very positive feedback on our research is encouraging because it validates the work we are doing.”

While the researchers are focused on understanding the role of CAV1 in breast and prostate cancer, they are also interested in how their current research may benefit other areas of biology in the future. .

“Our long-term goal is to facilitate biological discovery, for the improvement of human health, by bridging the gap between computational tools and biological issues,” says Hamarneh.

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* The collaboration between Hamarneh and the Nabi laboratories involved several graduate students and postdoctoral fellows who played a decisive role in this interdisciplinary research.

Warning: AAAS and EurekAlert! are not responsible for the accuracy of any press releases posted on EurekAlert! by contributing institutions or for the use of any information via the EurekAlert system.



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135. Requirements for clinical trials | Research integrity https://erudit.media/135-requirements-for-clinical-trials-research-integrity/ https://erudit.media/135-requirements-for-clinical-trials-research-integrity/#respond Wed, 26 May 2021 22:42:31 +0000 https://erudit.media/135-requirements-for-clinical-trials-research-integrity/ Updated May 26, 2021 Clinical trials must comply with a variety of requirements that do not apply to other types of human research. These requirements are designed to address the increased vulnerability of participants and the risks of many clinical trials relative to other research. They also aim to guarantee significant results. Here are some […]]]>


Updated May 26, 2021

Clinical trials must comply with a variety of requirements that do not apply to other types of human research. These requirements are designed to address the increased vulnerability of participants and the risks of many clinical trials relative to other research. They also aim to guarantee significant results. Here are some of the main requirements for clinical trials.

Requirement to publish consent form

Under the revised Human Research Protection Regulation (known as the revised “Common Rule”) which came into effect on January 21, 2019, an IRB-approved consent form used to register participants must be posted on a publicly accessible federal website for each clinical trial. funded by any federal agency or department that has adopted the common rule. For the purposes of this consent form display requirement, a “clinical trial” is defined in 45 CFR 46.102 (b) as: a research study in which one or more human subjects are prospectively assigned to one or more procedures (which may include a placebo or other controls) to assess the effects of interventions on biomedical or behavioral health outcomes.

Social, behavioral, and educational research studies funded by a Common Rules department or agency that meet the above definition of clinical trial must comply with the posting requirement. The informed consent form must be posted on the federal website after the clinical trial has closed upon enrollment, and no later than 60 days after participants’ last study visit, as required by protocol. If the federal department or agency that supports or is conducting the clinical trial determines that certain information should not be made public on a federal website (e.g., Confidential Business Information), the federal department or agency may authorize or require redactions of published information.

Recording and communication of clinical trial results

ClinicalTrials.gov is a publicly accessible registry and database of federally and privately funded clinical trials conducted in the United States and around the world. The purpose of ClinicalTrials.gov is to disclose to the public key information about clinical trials currently available or already conducted. ClinicalTrials.gov captures summary protocol information before and during the trial as well as summary results and adverse event information from a completed trial. Federal laws, regulations, and leading medical journal publishers require registration of a clinical trial, as described below.

An academic or affiliate researcher conducting a clinical trial must comply with these requirements if:

  • She or he is the Principal Investigator (PI), AND
  • The study is initiated by the investigator (the clinical trial is not an industrial trial in which the protocol is developed, owned and sponsored by a company. Industrial sponsors are responsible for registering their trials.)

Food and Drug Administration (FDA) Requirements

Registration is mandatory for studies that meet the definition of an “applicable clinical trial” (ACT) and that were initiated after September 27, 2007 or were initiated on or before that date and were still ongoing as of September 26, 2007. December 2007. Studies must be registered no later than 21 days after the registration of the first participant. The holder of any FDA IND, IDE, or HDE must ensure that these requirements are met.

National Institutes of Health (NIH) Requirements

Regardless of study phase or type of intervention, all NIH-funded clinical trials are expected to register and submit outcome information to Clinicaltrials.gov, in accordance with the “NIH Policy on Disclosure of Information. NIH-Funded Clinical Trials Information ”for competing applications and contract proposals. submitted on or after January 18, 2017. The Principal Fellow must ensure compliance. Studies must be registered no later than 21 days after the registration of the first participant. The NIH Principal Fellow is responsible for ensuring that these requirements are met.

International Committee of Medical Journal Editors (ICMJE)

For studies that plan to publish in medical journals, the ICMJE requires registration of clinical trials. Studies must be registered at the time of registration of the first participant at the latest

All investigator-initiated clinical trials that fall into one or more of the above categories must register with ClinicalTrials.gov to comply with the federal FDA requirements outlined in FDA 42 CFR 11 (final rule) and / or other federal agencies and departmental policy or requirements. Studies that fall under more than one registration requirement need only be registered once. Information published on ClinicalTrials.gov should be updated throughout the trial, checked at least every 12 months, and results should be provided at the end of the study.

Note: Even if a researcher-initiated clinical trial does not meet NIH or FDA clinical trial registration requirements, researchers are urged to read and consider registering your trial to comply with the additional requirements. of the International Committee of Medical Journal Editors (ICMJE). for publication purposes and other research funders who now need recording and reporting of results.

In the case of multi-site clinical trials, the primary PI for the entire study is the person responsible for meeting the requirements. If the University or Affiliate Researcher is the Principal Investigator only for the local site and is not the Principal Fellow or Principal Investigator of the study, then the Principal Investigator of the University or Affiliate is not responsible of the publication on ClinicalTrials.gov.

For more detailed guidance on clinical trial requirements, please visit the information page titled, Registration of Clinical Trial Information and Results Reporting Requirements available on the Research Integrity website.



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Volcano Watch – New research sheds light on recent Pāhala earthquake swarms https://erudit.media/volcano-watch-new-research-sheds-light-on-recent-pahala-earthquake-swarms-2/ https://erudit.media/volcano-watch-new-research-sheds-light-on-recent-pahala-earthquake-swarms-2/#respond Fri, 21 May 2021 00:10:13 +0000 https://erudit.media/volcano-watch-new-research-sheds-light-on-recent-pahala-earthquake-swarms-2/ Volcano Watch is a weekly article and activity update written by scientists and affiliates of the US Geological Survey Hawaiian Volcano Observatory. The increase in earthquakes in recent years, which is currently at a historically high rate, is of interest to residents and scientists alike. These earthquakes occur under our volcanoes and even under the […]]]>


Volcano Watch is a weekly article and activity update written by scientists and affiliates of the US Geological Survey Hawaiian Volcano Observatory.

The increase in earthquakes in recent years, which is currently at a historically high rate, is of interest to residents and scientists alike.

These earthquakes occur under our volcanoes and even under the base of the underlying oceanic crust, in the upper mantle. This part of the mantle is called the lithospheric mantle because it is cold enough to rupture and create earthquakes. The deeper mantle is too hot and too plastic to generate earthquakes and tends to sink like putty or clay.

Historically, earthquakes in the lithospheric mantle, like those under Pāhala and elsewhere in Hawaii, occur in response to the weight of the island bending the lithospheric mantle down. The magnitude 6.9 earthquake in Kīholo Bay in 2006 was a prime example of this type of “bending” earthquake.

Several ideas have been put forward about the cause of earthquakes deep beneath Pāhala and the southeastern coast of Kaʻū since their first observation in the late 1960s. The initial hypothesis was that these earthquakes occurred on planes of fault and are linked to the flexion of the lithospheric mantle due to the weight of the overlying volcanoes. However, the deep Pāhala earthquakes differ from other lithospheric earthquakes under Hawaii in the large number of earthquakes, especially since 2015.

Other authors have suggested that the region deep beneath Pāhala was a pathway for magma from the upper mantle plume below the island of Hawaii to the Kīlauea volcano. They hypothesized that the number of earthquakes increased when the magma was supplied to Kīlauea, although there is no direct evidence to support a movement of the magma and that it requires a still unidentified conduit to move the magma over great distances horizontally to pass under Kīlauea and Mauna Loa.

Scientists recently examined the characteristics of the strong seismicity that began under Pāhala in 2015. They found that as the number of earthquakes began to increase, many earthquakes occurred on steep faults as well as on faults historically interpreted as flat. The number of earthquakes increased again in 2019, as did the variety of faults that produce them.

The overall load of volcanoes on the lithosphere would not change significantly in a few years, so the variety of fault orientations requires a more complex answer to explain the large number of earthquakes and their change in orientation. The Pāhala region is located at the structural link between three volcanoes – Kīlauea, Mauna Loa and Lō’ihi. However, there is insufficient information to make a link between the accumulation of stresses in this region and the generation of these seismic swarms.

Instead, scientists speculated that magma could escape from the mantle plume and migrate into the Pāhala region and stall at depth. The inferred magma could pressurize the region, causing an increase in the number and variety of earthquakes occurring under Pāhala. While there is no direct evidence that magma is accumulating, it is an interesting hypothesis that warrants further investigation.

The Pāhala earthquake swarm in its current state appears to be a unique event that has never been observed before in Hawai’i, although the historic record for seismographs dates back just over 50 years. Further research is planned and involves placing a dense network of tiny temporary seismometers at Ka’ū to visualize what’s going on deep below Pāhala. If you get a call from a USGS Hawaiian Volcanoes Observatory or a University of Hawaii scientist looking to place a small instrument on your land next year, engage with them and do what you can to help expand our understanding of this complex system by supporting this important and interesting volcanic research.

Map and graph showing earthquakes at a depth of 20 to 40 km (12 to 25 miles) below the island of Hawaii over the past week. Most of the earthquakes at this depth were clustered under the southern edge of the island near the town of Pāhala (blue dots). USGS chart.

(Public domain.)

Volcano activity updates

The Kīlauea volcano is erupting. Its USGS volcano alert level is at WATCH (https://www.usgs.gov/natural-hazards/volcano-hazards/about-alert-levels). Kīlauea updates are released daily.

Lava activity is confined to Halema’uma’u with lava erupting from a vent on the northwest side of the crater. Laser range finder measurements this morning, May 20, indicate that the lava in the western (active) part of the lake is 229m (751ft) deep, with most of the lava lake solidifying on the surface. The summit inclinometers have recorded minor changes over the past 24 hours. The sulfur dioxide emission rates measured on May 18 were 100 t / d. Seismicity remains stable, with high tremors. For the most recent information on the eruption, see https://www.usgs.gov/volcanoes/kilauea/current-eruption.

Mauna Loa is not erupting and remains at the AVIS volcano alert level. This alert level does not mean that an eruption is imminent or that progression to an eruption from the current level of unrest is certain. Mauna Loa updates are released weekly.

Last week, around 113 low-magnitude earthquakes were recorded under Mauna Loa; most of these occurred below the summit and above elevations at depths less than 8 kilometers (about 5 miles). Global Positioning System (GPS) measurements show low rates of deformation in the summit region over the past week. The gas concentrations and the temperatures of the fumaroles at the summit and at Sulfur Cone in the southwest rift zone remain stable. The webcams do not show any change in the landscape. For more information on the current monitoring of Mauna Loa volcano, see: https://www.usgs.gov/volcanoes/mauna-loa/monitoring.

There have been 2 events with 3 or more felt reports in the Hawaiian Islands in the past week: an M3.2 earthquake 4 km (2 mi) west of Pāhala 33 km (20 mi) deep on May 19 at 3:18 a.m. HST and an M2.8 earthquake 1 km (0 mi) southwest of Pāhala at a depth of 33 km (20 mi) on May 17 at 2:41 p.m. HST.

The HVO continues to closely monitor both the ongoing eruption of Kīlauea and Mauna Loa for any signs of increased activity.

Please visit the HVO website for previous articles on Volcano Watch, Kīlauea and Mauna Loa updates, volcano photos, maps, information on recent earthquakes, and more. Email your questions to askHVO@usgs.gov.

Volcano Watch is a weekly article and activity update written by scientists and affiliates of the US Geological Survey Hawaiian Volcano Observatory.



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Research team finds additional CWD prions at Beltrami County deer farm landfill site https://erudit.media/research-team-finds-additional-cwd-prions-at-beltrami-county-deer-farm-landfill-site-3/ https://erudit.media/research-team-finds-additional-cwd-prions-at-beltrami-county-deer-farm-landfill-site-3/#respond Thu, 20 May 2021 23:34:00 +0000 https://erudit.media/research-team-finds-additional-cwd-prions-at-beltrami-county-deer-farm-landfill-site-3/ In early April, the Minnesota Animal Health Board confirmed that a 3-year-old white-tailed doe on a Beltrami County deer farm tested positive for CWD. The most northerly case in Minnesota, the deadly deer disease had been confirmed in Minnesota. RELATED STORIES: According to a press release from the U of M, university scientists found the […]]]>


In early April, the Minnesota Animal Health Board confirmed that a 3-year-old white-tailed doe on a Beltrami County deer farm tested positive for CWD. The most northerly case in Minnesota, the deadly deer disease had been confirmed in Minnesota.

RELATED STORIES:

According to a press release from the U of M, university scientists found the prions causing CWD in a single sample of bone marrow, using a technology known as RT-QuIC which can be used to identify prions. of CWD in carcasses and in the environment.

Faster and more accurate tests that can be used on a wide variety of sample types are essential to improve efforts to limit the spread of CWD, a transmissible neurological disease that is still fatal to white-tailed deer, the researchers said. scientists.

“It’s a rapidly changing situation. We are pleased to have been able to assist our staff at the Minnesota Department of Natural Resources, the Minnesota Board of Animal Health and the US Department of Agriculture with the RT-QuIC testing of carcasses, ”Peter Larsen, who led the team and co -Direct the University’s Minnesota Center for Prion Research and Awareness (MNPRO), said in a press release. “Our work is helping everyone respond faster by taking action to protect our collective white-tailed deer resources. The identification of a positive carcass in an area frequented by wild white-tailed deer is of great concern. Our MNPRO team is ready to help secure the landfill site to try and prevent CWD from spreading to surrounding wild herds. “

On May 2, the team collected bone, skin, soil and plant samples from the site. Their expertise in deer anatomy and wild animal mortality investigations has enabled them to find servings of 10 or more deer, according to the press release. In addition, their knowledge of the conditions that favor the survival of CWD-responsible prions allowed them to focus on collecting and processing samples obtained from highly deteriorated and desiccated materials with a high probability of retaining the prions of the CWD. months or years after their filing.

The herd at the nearby deer farm was depopulated last week, and samples of these deer have been collected by the US Department of Agriculture for official MDC testing. MNPRO obtained additional research samples from depopulated animals.

Further testing of carcass samples on hand, as well as future collection and analysis of additional samples at the carcass site, is dependent on additional funding from MNPRO, the university press release said.

Following the recent discovery of CWD in Beltrami County, MNR is developing a response plan that will include increased surveillance and a deer feeding ban that will be implemented sometime before the hunting season. deer this fall. Minnesota has documented about 115 cases of CWD in wild deer since the first confirmed report in 2010, according to MNR statistics.

“It’s such a geographic leap to where we’ve seen the disease, and that now means we’re going to have to do surveillance activities in this area surrounding this facility in Beltrami County,” MNR Commissioner Sarah Strommen said last week in an interview with the Herald. “It’s the heart of deer country over there, so it’s worrying and we want to be proactive about it.”

The MNPRO team also recently developed a new test that generates a color change from red for a positive CWD result and blue for a negative result. They named the test “MN-QuIC” to honor the state of Minnesota, where the test was developed. The new test is less expensive than those using traditional equipment and uses field deployable equipment to get preliminary results in just 24 hours. The team is working to obtain a test that could be used at individual stations, thereby reducing bottlenecks during the deer hunting season.

MN-QuIC is another promising tool for rapid sample screening in forensic investigations such as Beltrami County.

Fatal to members of the deer family, collectively referred to as cervids, CWD is transmitted by misfolded prion proteins, the same process that causes scrapie, bovine spongiform encephalopathy in cattle (sometimes referred to as “bovine disease). mad cow ‘) and sporadic Creutzfeldt-Jakob disease in humans. The prions responsible for CWD are not alive and can only be destroyed with specialized equipment or strong chemicals, which makes CWD so difficult to mitigate. They can also persist in the environment for years. Progress on CWD could inform other prion-related diseases in humans and animals.

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Sanford Receives $ 12 Million NIH Grant for Eating Disorders Research https://erudit.media/sanford-receives-12-million-nih-grant-for-eating-disorders-research/ https://erudit.media/sanford-receives-12-million-nih-grant-for-eating-disorders-research/#respond Thu, 20 May 2021 23:30:00 +0000 https://erudit.media/sanford-receives-12-million-nih-grant-for-eating-disorders-research/ FARGO – The Sanford Research Center for Biobehavioral Research has just received a $ 12 million Center of Excellence in Biomedical Research (COBRE) grant from the National Institutes of Health. The COBREs support the development of centers of excellence in biomedical and behavioral research. The Sanford Center for Biological Behavioral Research, COBRE, is titled “Center […]]]>


FARGO – The Sanford Research Center for Biobehavioral Research has just received a $ 12 million Center of Excellence in Biomedical Research (COBRE) grant from the National Institutes of Health.

The COBREs support the development of centers of excellence in biomedical and behavioral research. The Sanford Center for Biological Behavioral Research, COBRE, is titled “Center for Biobehavioural Mechanisms of Eating Behavior” and will focus on the processes that lead to the development of eating disorders such as anorexia, bulimia and ‘obesity.

Up to 400 people a year – from across the country – come to the Sanford Eating Disorder Center in Fargo. Now, with the news of a $ 12 million NIH grant, those on the eating disorder research side will be tackling the problem from the science side.

“Our end goal is to find out how to treat our patients more effectively and by studying the underlying processes and mechanisms of these disorders we can make better treatments,” said Dr Stephen Wonderlich, health researcher at Sanford.

Dr Wonderlich has worked alongside eating disorder patients for 35 years at Fargo. He and his fellow researcher, Dr Ross Crosby, are known across the country for their work. They say the multi-million dollar grant will finally mean a comprehensive infrastructure and research facility that will ultimately change the lives of the 30 million people living with the disease across the country.

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“This is why we are so excited, because we have the opportunity to conduct research that will ultimately benefit these individuals and their families, the people who care for them,” said Dr. Crosby. “That’s our goal, and this grant allows us to do that, to expand and develop more research.”

The NIH COBRE grant will support the development of a comprehensive center for scientific research in the field of eating disorders. This award will allow Sanford Health, along with their grant collaborators, North Dakota State University, North Dakota University, and several other universities across the United States to develop a unique and cutting-edge scientific center that could have a significant impact on the lives of individuals. suffering from eating disorders.

“It comes down to the patient and their family, that’s our goal,” Wonderlich said. “To find out how to provide better care.”

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New research explains why barramundi changes gender https://erudit.media/new-research-explains-why-barramundi-changes-gender/ https://erudit.media/new-research-explains-why-barramundi-changes-gender/#respond Mon, 17 May 2021 01:38:12 +0000 https://erudit.media/new-research-explains-why-barramundi-changes-gender/ CDU New research from a Charles Darwin University doctoral student has found that the timing of sex change in barramundi is more related to height than age. Most barramundi are sequential hermaphrodites – starting life as males before becoming female later in life. Research undertaken by CDU doctoral student Brien Roberts found that a faster […]]]>


CDU

New research from a Charles Darwin University doctoral student has found that the timing of sex change in barramundi is more related to height than age.

Most barramundi are sequential hermaphrodites – starting life as males before becoming female later in life.

Research undertaken by CDU doctoral student Brien Roberts found that a faster growing barramundi will change sex at a younger age.

“Most barra start life as men, then grow into women later in life – that’s why most of the great ‘meterys’ are women,” said Mr Roberts.

“These large females are by far the most valuable breeders in the population.

“There is a limited evolutionary benefit to being a small barramundi female, as a larger female can produce more eggs and will be much more successful in passing on her genes.”

Mr Roberts said his research has shown that the timing of sex change in barramundi is more related to height than age.

“A faster growing barra will change sex at a younger age than a slower growing fish because it will reach ‘threshold’ size faster,” he said.

“Becoming female at a younger age means that a fish spends more of its life being female – and more time producing a baby barra.”

The research looked at barramundi captured from the Fitzroy River in Western Australia, but the results apply to barramundi in all tropical rivers in northern Australia, including the Kakadu Wetlands, listed by Ramsar.

In addition to being the most popular fishing fish in the Top End, barramundi is also very popular with traditional owners for food and cultural reasons.

The Top End has had its best rainy season in nearly five years, with rainfall in the NT between October 2020 and February 2021 around 32% above the long-term average, the highest since 2016-17.

An exceptional wet season will be good news for the barramundi population of the Northern Territory.

Mr Roberts said the healthy soaking kept river flow intact and allowed floodplains to be flooded more often, ensuring healthy barra populations for the future.

“The age at which barramundi mature as females depends on the environmental conditions they face as juvenile fish,” he said.

“The great rainy seasons provide good food and habitat for the barra juveniles, allowing them to grow and mature faster, develop into females earlier and produce more barra babies for the future.

The research is funded by the Australian Government’s National Environmental Science Program through the Northern Australia Environmental Resources Hub. It also involved scientists from the University of Melbourne, the University of Murdoch and NT Fisheries.

/ Public publication. This material is from the original organization and may be ad hoc in nature, edited for clarity, style and length. See it in full here.



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Analysis, characterization and quantification of spa market research and major suppliers such as Bullfrog Spas, Canadian Spa Company, Jacuzzi, Artesian Spas, Blue Falls Manufacturing, etc. – KSU https://erudit.media/analysis-characterization-and-quantification-of-spa-market-research-and-major-suppliers-such-as-bullfrog-spas-canadian-spa-company-jacuzzi-artesian-spas-blue-falls-manufacturing-etc-ksu/ https://erudit.media/analysis-characterization-and-quantification-of-spa-market-research-and-major-suppliers-such-as-bullfrog-spas-canadian-spa-company-jacuzzi-artesian-spas-blue-falls-manufacturing-etc-ksu/#respond Mon, 17 May 2021 01:02:09 +0000 https://erudit.media/analysis-characterization-and-quantification-of-spa-market-research-and-major-suppliers-such-as-bullfrog-spas-canadian-spa-company-jacuzzi-artesian-spas-blue-falls-manufacturing-etc-ksu/ “ Spas Market Report Coverage: Key growth factors and challenges, regional segmentation and outlook, key industry trends and opportunities, competitive analysis, COVID-19[female[feminine Impact analysis and projected recovery, and market sizing and forecasting. A detailed report on Global Spa market To provide comprehensive information on the current market situation and offer solid insight into the potential […]]]>


Spas Market Report Coverage: Key growth factors and challenges, regional segmentation and outlook, key industry trends and opportunities, competitive analysis, COVID-19[female[feminine Impact analysis and projected recovery, and market sizing and forecasting.

A detailed report on Global Spa market To provide comprehensive information on the current market situation and offer solid insight into the potential market size, volume and dynamics during the forecast period 2021-2027. The research study offers a comprehensive analysis of critical aspects of the global spa market including competition, segmentation, geographic advancements, manufacturing cost analysis, and price structure. We have provided TCCA, value, volume, sales, production, revenue and other estimates for global and regional markets.

The major key players described in the report include: Bullfrog Spas, Canadian Spa Company, Jacuzzi, Artesian Spas, Blue Falls Manufacturing, Cal Spas, CalderaSpas, Coast Spas, Nordic Products, MARQUIS, Premium Leisure and more…

Download a free sample PDF including full table of contents, tables and figures @
https://www.marketinforeports.com/Market-Reports/Request-Sample/332022

Don’t miss the trading opportunities at Hot Tub Market. Speak to our analyst and get key industry insights that will help your business grow when you create sample PDF reports.

The regional study of the Global Hot Tubs Market explains how different regions and different markets at country level are evolving. In addition, it gives a statistical representation of their progress during the forecast period. Our analysts used PPrimary and secondary research methodologies to compile the research study on the global Hot Tub market.

Market segment by type, covers:
Above ground spas
Drinking spas
Underground spas

The market segment by applications can be divided into:
Residential users
Commercial users

Competitive landscape: Competitive landscape of a market explains competition in the Hot Tub market taking into account price, revenue, sales and market share by company, market concentration rate, competitive situation, trends and market shares of the main companies. The strategies incorporated by the major vendors in the market such as investment strategies, marketing strategies, and product development plans are also included in the report. The research integrates data regarding the producer’s product line, major product applications and product specifications.

Get a chance to 40% Extra discount, If your company is in the above list of key players @
https://www.marketinforeports.com/Market-Reports/Request_discount/332022

The authors of the report have analyzed the developing regions and the developed regions considered for the research and analysis of the global spa market. The regional analysis section of the report provides in-depth research study on different regional and national spa industries to help players plan effective expansion strategies.

Regions Covered in the Global Spa Market:
The Middle East and Africa (GCC countries and Egypt)
North America (United States, Mexico and Canada)
South America (Brazil etc.)
Europe (Turkey, Germany, Russia, United Kingdom, Italy, France, etc.)
Asia Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia and Australia)

Years considered to estimate the market size:
Year of history: 2015-2019
Base year: 2019
Estimated year: 2021
Forecast year: 2021-2026

Contents: Global Hot Tub Market Research Report 2021-2026

Chapter 1 Spa Market Overview
Chapter 2 Global economic impact on industry
chapter 3 Competition in the world market by manufacturers
Chapter 4 World production, income (value) by region
Chapter 5 Global supply (production), consumption, export, import by regions
Chapter 6 World production, revenue (value), price trend by type
Chapter 7 Global Market Analysis by Application
Chapter 8 Manufacturing cost analysis
Chapter 9 Industrial chain, sourcing strategy and downstream buyers
Chapter 10 Analysis of the marketing strategy, distributors / traders
Chapter 11 Analysis of market effect factors
Chapter 12 Global Spa Market Forecast

To learn more about the report, visit @ https://www.marketinforeports.com/Market-Reports/332022/Hot-Tub-market

What market dynamics does this report cover?
The report shares key information on:

  • Current market size
  • Market forecast
  • Market opportunities
  • Main drivers and constraints
  • Regulatory scenario
  • Industry trend
  • New product approvals / launches
  • Promotion and marketing initiatives
  • Price Analysis
  • Competitive landscape

It helps companies make strategic decisions.

Does this report offer customization?
Personalization helps organizations better understand specific market segments and areas of interest. Therefore, Market information reports provides customized reporting information based on business needs for strategic calls.

Get Report Customization @:
https://www.marketinforeports.com/Market-Reports/Request-Customization/332022/Hot-Tub-market

Why Choose Market Information Reports ?:
Market Information Reports Research provides strategic market research reports, industry analysis, statistical surveys, and forecast data on products and services, markets, and companies. Our client base includes a mix of global business leaders, government organizations, SMEs, individuals and start-ups, top management consulting firms, universities, and more. Our library of over 600,000 reports targets high-growth emerging markets in the United States, Europe Middle East, Africa, Asia-Pacific covering industries like IT, telecommunications, chemicals, semiconductors, healthcare, pharmaceuticals, energy and electricity, manufacturing, automotive and transport, food and drink, etc.. This expansive collection of insightful reports helps customers stay ahead of the times and the competition. We assist in business decision making on aspects such as market entry strategies, market size, market share analysis, sales and revenue, technology trends, competitive analysis, product portfolio and application analysis, etc.

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Earthquake agency sets direction for research funding https://erudit.media/earthquake-agency-sets-direction-for-research-funding/ https://erudit.media/earthquake-agency-sets-direction-for-research-funding/#respond Mon, 17 May 2021 00:04:57 +0000 https://erudit.media/earthquake-agency-sets-direction-for-research-funding/ The National Earthquake Commission (EQC) has said it wants to ensure its research funding is focused on studies that give the agency the best results for its mission and for its resilience goal of see New Zealanders have stronger homes on better land, connected by resilient infrastructure – and access to home insurance. EQC has […]]]>


The National Earthquake Commission (EQC) has said it wants to ensure its research funding is focused on studies that give the agency the best results for its mission and for its resilience goal of see New Zealanders have stronger homes on better land, connected by resilient infrastructure – and access to home insurance.

EQC has released its latest Research Priority Investment Statement (RIPS) for the research funding cycle that begins in June.

Future investment in research

The areas that will guide CQE’s research investments aim to improve understanding of:

  • How people perceive and manage risk (empowering people)
  • Performance of buildings and infrastructure (resilient buildings) •
  • Land use management (smarter land use)
  • The governance and economics of disaster risk and disaster risk management
  • Quantification of the size and frequency / likelihood of hazards and their impacts. In addition to these areas of interest, we have identified three lenses that we encourage researchers to apply to their projects:
  • Matauranga Maori (Maori knowledge)
  • Climate change
  • Social science.

The EQC says it is not its priority to fund basic research on climate change, such as modeling or forecasting, but it is interested in how climate change can influence the frequency and the seriousness of the natural risks covered by the EQC, and any subsequent impact on the achievement of the CQE. its resilience goals.

Funding

EQC funds approximately NZ $ 20 million ($ 14.5 million) of research and data each year, of which approximately NZ $ 14 million goes to GeoNet, a collaboration between the Earthquake Commission and GNS Science, a New Zealand Crown research institute focused on geology and geophysics. and nuclear science. The remaining NZ $ 6 million is used to fund specific science and data projects, partnerships and prizes.

“But deciding which of the many possible projects to fund is never easy,” said Dr Natalie Balfour, EQC’s research director.

She said the RIPS “gives researchers a very clear idea of ​​what the EQC will and will not consider”. She added: “For example, even though we know that climate change will make some of the risks we cover – like flooding or landslides from storms – more likely, we will not fund basic research on climate change. , such as modeling and forecasting. “

The EQC is a New Zealand state entity that invests in natural disaster research, education and provides insurance to residential property owners.



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Researchers turn to radio to spotlight NH agriculture | Environment https://erudit.media/researchers-turn-to-radio-to-spotlight-nh-agriculture-environment/ https://erudit.media/researchers-turn-to-radio-to-spotlight-nh-agriculture-environment/#respond Mon, 17 May 2021 00:00:00 +0000 https://erudit.media/researchers-turn-to-radio-to-spotlight-nh-agriculture-environment/ Researchers at the New Hampshire Agricultural Experiment Station will take center stage in May and June in a series of radio talks. “The purpose of these spots is to introduce and expand listeners’ knowledge about the diversity of New Hampshire agriculture,” said Gail McWilliam Jellie of the Department of Agriculture, Markets and Food of the […]]]>


Researchers at the New Hampshire Agricultural Experiment Station will take center stage in May and June in a series of radio talks.

“The purpose of these spots is to introduce and expand listeners’ knowledge about the diversity of New Hampshire agriculture,” said Gail McWilliam Jellie of the Department of Agriculture, Markets and Food of the state.

The interviews will air on 99.7 WNTK news talk radio at 9:15 a.m. on May 27 and June 10 and 24.

“We are working in partnership with all of the farm organizations in New Hampshire to give everyone a chance to tell their story and again to illustrate the scale of the agriculture industry in our state,” Jellie said in a press release. . “The experimentation station shows this perfectly with all the different research projects focused on improving agriculture.”

NH’s Agricultural Experiment Station Director Anton Bekkerman said researchers were “looking for answers to locally-inspired questions that remain unanswered to ensure sustainable, vibrant and economically resilient agriculture and food systems” in the ‘State.

On May 27, longtime station scientist Becky Sideman will talk about her research on seedless table grapes, including varieties that grow well in New Hampshire.

Station researcher Pete Erickson will launch National Milk Month on June 10 to discuss the nutrition of dairy cattle, as well as his most recent research on the use of wet brewers grains as profitable dairy foods.

On June 24, researchers David Plachetzki and Sydney Birch will discuss ways to deter a jellyfish-like animal from living on fish farm nets and equipment – research that aims to solve a million-dollar puzzle dollars for the aquaculture industry.



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